Identification and Annotation of Peptide Allergens in Prunus dulcis

Approximately, 10% of the world population is facing challenge food allergy in direct or indirect way. In this study, a genome-wide identification and annotation novel putative allergen from almond performed. Initially, whole proteome (31,000 proteins) was scanned by Allergenonline, publically available database already reported allergens different sources. The detailed analysis suggests that there are 430 which reduced to 45 on motif-based screening using AllFam database. These predicted annotated for their function PFAM, GO databases orthology analysis. To validate our prediction, we have used structural insights antibody interactions one protein, homologous Pru ar 3.0101allergen apricot. structure modeled molecular docking studies were performed against antibody. best docked conformation subjected simulation confirm stable binding these two molecules. This identified will show cross reactivity similar 3.0101 first report identifying annotating almond.